Effect of Electroacupuncture with Different Current Intensities on the Serum Metabolomics of Functional Constipation

Objective. The aim of the study is to investigate serum metabolomics electroacupuncture (EA) with different current intensities in treatment functional constipation (FC). Methods. total number FC patients was 19, (7, 6, low intensity group (LCI), high (HCI), and mosapride citrate tablet control (MC), respectively). Patients EA groups received 16 sessions acupuncture treatments. MC were orally administered 5 mg tablets 3 times daily, samples collected from before after treatment. Orthogonal partial least square-discriminant analysis (OPLS-DA) used assess metabolic data. significant differences are shown OPLS-DA score plot. Variable importance plots (VIPs) T tests identify metabolites. Results. Among three groups, metabolites VIP > 1 11, 7, 21 (in LCI, HCI Compared those treatment, characterized by increased levels L-ornithine ( p < 0.05) glyceric acid LCI id="M2"> 0.05), vanillic id="M3"> decreased arabinonic id="M4"> 0.05). Conclusions. effects on may involve fatty amino metabolism.